Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding Protein (OBPIIa) Gene

Giorgia Sollai
;
Melania Melis;Mariano Mastinu;Danilo Paduano;Fabio Chicco;Salvatore Magri;Paolo Usai;Thomas Hummel;Iole Tomassini Barbarossa
Penultimo
;
Roberto Crnjar
Ultimo
2021-01-01

Abstract

Smell strongly contributes to food choice and intake, influencing energy balance and body weight; its reduction or loss has been related to malnutrition problems. Some patients with inflammatory bowel disease (IBD), mainly Crohn’s disease (CD) and ulcerative colitis (UC), are underweight, while others are overweight. Some studies suggest that changes in eating habits could be linked to specific disorders of the olfactory functions. We assessed the olfactory performance in 199 subjects (healthy control (HC) n = 99, IBD n = 100), based on the olfactory Threshold, Discrimination and Identification score (TDI score), measured with the “Sniffin’ Sticks” test. Subjects were genotyped for the rs2590498 polymorphism of the OBPIIa gene. IBD patients showed both a slightly, but significantly, lower olfactory function and a higher BMI compared to HC subjects. Threshold (in both population) and Discrimination (in IBD patients) olfactory score were affected by the OBPIIa genotype. BMI was influenced by both health status and OBPIIa genotype. A lower olfactory function may delay the satiety sensation and thus increase meal duration and body weight in IBD patients. However, the AA genotype of the OBPIIa seems to “protect” IBD patients from more severe olfactory dysfunction.
2021
Inglese
13
2
703
1
15
15
Esperti anonimi
internazionale
scientifica
smell; olfactory dysfunction; Crohn’s disease (CD) and ulcerative colitis (UC); odorant binding proteins (OBPs) gene; BMI; nutrition
Sollai, Giorgia; Melis, Melania; Mastinu, Mariano; Paduano, Danilo; Chicco, Fabio; Magri', Salvatore; Usai, Paolo; Hummel, Thomas; TOMASSINI BARBAROSSA, Iole; Crnjar, ROBERTO MASSIMO
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
10
open
File in questo prodotto:
File Dimensione Formato  
2021_Olfactory function in patients with IBD is associated with their BMI and...._Sollai et al 2021.pdf

accesso aperto

Tipologia: versione editoriale
Dimensione 1.15 MB
Formato Adobe PDF
1.15 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Questionario e social

Condividi su:
Impostazioni cookie