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Titolo Data di pubblicazione Autore(i) Rivista Editore
Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication 2018 Sanna, Cinzia; Scognamiglio, Monica; Fiorentino, Antonio; Corona, Angela; Graziani, Vittoria; Car...edda, Alessia; Cortis, Pierluigi; Montisci, Mariofilippo; Rita Ceresola, Elisa; Canducci, Filippo; Poli, Ferruccio; Tramontano, Enzo; Esposito, Francesca PLOS ONE
HERV-W group evolutionary history in non-human primates: Characterization of ERV-W orthologs in Catarrhini and related ERV groups in Platyrrhini 2018 Grandi, Nicole; Cadeddu, Marta; Blomberg, Jonas; Mayer, Jens; Tramontano, Enzo BMC EVOLUTIONARY BIOLOGY
Structure-guided approach identifies a novel class of HIV-1 Ribonuclease H inhibitors: Binding mode insights through magnesium complexation and site-directed mutagenesis studies 2018 Poongavanam, Vasanthanathan; Corona, Angela; Svendsen, Casper; Scipione, Luigi; Grandi, Nicole; P...andolfi, Fabiana; Di Santo, Roberto; Costi, Roberta; Esposito, Francesca; Tramontano, Enzo; Kongsted, Jacob MEDCHEMCOMM
Onopordum illyricum L., a Mediterranean plant, as a source of anti HIV-1 compounds 2018 Sanna, C.; Rigano, D.; Cortis, P.; Corona, A.; Ballero, M.; Parolin, C.; Del Vecchio, C.; Chianes...e, G.; Saccon, E.; Formisano, C.; Tramontano, E.; Esposito, F. PLANT BIOSYSTEMS
Human endogenous retroviruses are ancient acquired elements still shaping innate immune responses 2018 Grandi, Nicole; Tramontano, Enzo FRONTIERS IN IMMUNOLOGY
Insights into the homo-oligomerization properties of N-terminal coiled-coil domain of Ebola virus VP35 protein 2018 Ramaswamy, VENKATA KRISHNAN; DI PALMA, Francesco; Vargiu, Attilio V.; Corona, Angela; Piano, Dari...o; Ruggerone, Paolo; Zinzula, Luca; Tramontano, Enzo VIRUS RESEARCH
Identification of Myricetin as Ebolavirus VP35-dsRNA interaction inhibitor through a novel fluorescence-based assay 2018 Luca Daino, Gian; Frau, Aldo; Sanna, Cinzia; Rigano, Daniela; Distinto, Simona; Madau, Veronica; ...Esposito, Francesca; Fanunza, Elisa; Bianco, Giulia; Taglialatela-Scafati, Orazio; Zinzula, Luca; Maccioni, Elias; Corona, Angela; Tramontano, Enzo BIOCHEMISTRY
Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion 2017 Grandi, Nicole; Cadeddu, Marta; Pisano, Maria Paola; Esposito, Francesca; Blomberg, Jonas; Tramon...tano, Enzo MOBILE DNA
Broad-range potential of Asphodelus microcarpus leaves extract for drug development 2017 DI PETRILLO, Amalia; Fais, Antonella; Pintus, Francesca; Santos Buelga, Celestino; Gonzalez Param...as, Ana M.; Piras, Vincenzo; Orru, Germano; Mameli, Antonello; Tramontano, Enzo; Frau, Aldo BMC MICROBIOLOGY
Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase 2017 Sonar, Vijay P.; Corona, Angela; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Fois, Benedett...a; Floris, Costantino; Malpure, Nilesh V.; Alcaro, Stefano; Tramontano, Enzo; Cottiglia, Filippo EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase 2017 Meleddu, Rita; Distinto, Simona; Corona, Angela; Tramontano, Enzo; Bianco, Giulia; Melis, Claudia...; Cottiglia, Filippo; Maccioni, Elias JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Chelation motifs affecting metal-dependent viral enzymes: N′-acylhydrazone ligands as dual target inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H domain 2017 Carcelli, Mauro; Rogolino, Dominga; Gatti, Anna; Pala, Nicolino; Corona, Angela; Caredda, Alessia...; Tramontano, Enzo; Pannecouque, Christophe; Naesens, Lieve; Esposito, Francesca FRONTIERS IN MICROBIOLOGY
Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding 2017 Martini, Riccardo; Esposito, Francesca; Corona, Angela; Ferrarese, Roberto; Ceresola, Elisa Rita;... Visconti, Laura; Tintori, Cristina; Barbieri, Alessandro; Calcaterra, Andrea; Iovine, Valentina; Canducci, Filippo; Tramontano, Enzo; Botta, Maurizio CHEMBIOCHEM
Type W Human Endogenous Retrovirus (HERV-W) Integrations and Their Mobilization by L1 Machinery: Contribution to the Human Transcriptome and Impact on the Host Physiopathology 2017 Grandi, Nicole; Tramontano, Enzo VIRUSES
Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions 2017 Corona, Angela; Onnis, Valentina; Deplano, Alessandro; Bianco, Giulia; Demurtas, Monica; Distinto..., Simona; Cheng, Yung Chi; Alcaro, Stefano; Esposito, Francesca; Tramontano, Enzo PATHOGENS AND DISEASE
Ebola virus VP35 blocks stress granule assembly 2017 Le Sage, Valerie; Cinti, Alessandro; McCarthy, Stephen; Amorim, Raquel; Rao, Shringar; Daino, Gia...n Luca; Tramontano, Enzo; Branch, Donald R; Mouland, Andrew J VIROLOGY
Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action 2017 Esposito, Francesca; Mandrone, Manuela; Del Vecchio, Claudia; Carli, Ilaria; Distinto, Simona; Co...rona, Angela; Lianza, Mariacaterina; Piano, Dario; Tacchini, Massimo; Maccioni, Elias; Cottiglia, Filippo; Saccon, Elisa; Poli, Ferruccio; Parolin, Cristina; Tramontano, Enzo PATHOGENS AND DISEASE
Meeting report: Third Summer School on innovative approaches for identification of antiviral agents (IAAASS) 2017 Le Grice, Stuart FJ; Sztuba-Solinska, Joanna; Maccioni, Elias; Purzycka, Katarzyna J; Parolin, Cr...istina; Tramontano, Enzo ANTIVIRAL RESEARCH
Inhibition of HIV-1 reverse transcriptase dimerization by small molecules 2016 Tintori, C; Corona, A; Esposito, F; Brai, A; Grandi, N; Ceresola, ER; Clementi, M; Canducci, F; T...ramontano, E; Botta, M CHEMBIOCHEM
Ribonuclease H/DNA polymerase HIV-1 reverse transcriptase dual inhibitor: mechanistic studies on the allosteric mode of action of isatin-based compound RMNC6 2016 Corona, A; Meleddu, R; Esposito, F; Distinto, S; Bianco, G; Masaoka, T; Maccioni, E; Menéndez-Ari...as, L; Alcaro, S; Le Grice, SFJ; Tramontano, E PLOS ONE
Classification and characterization of human endogenous retroviruses; mosaic forms are common 2016 Vargiu, L; Rodriguez-Tomé, P; Sperber, GO; Cadeddu, M; Grandi, N; Blikstad, V; Tramontano, E; Blo...mberg, J RETROVIROLOGY
A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity 2016 Palomba, M.; Rossi, L.; Sancineto, L.; Tramontano, E.; Corona, A.; Bagnoli, L.; Santi, C.; Pannec...ouque, C.; Tabarrini, O.; Marini, F ORGANIC & BIOMOLECULAR CHEMISTRY
The S-layer protein DR_2577 binds deinoxanthin and under desiccation conditions protects against UV-radiation in Deinococcus radiodurans 2016 Farci, D; Slavov, C; Tramontano, Enzo; Piano, Dario FRONTIERS IN MICROBIOLOGY
Contribution of type W human endogenous retroviruses to the human genome: Characterization of HERV-W proviral insertions and processed pseudogenes 2016 Grandi, Nicole; Cadeddu, Marta; Blomberg, Jonas; Tramontano, Enzo RETROVIROLOGY
Biological activities of aerial parts extracts of Euphorbia characias 2016 Pisano, MARIA BARBARA; Cosentino, Sofia; Viale, Silvia; Spano', Delia; Corona, Angela; Esposito, ...Francesca; Tramontano, Enzo; Montoro, P; Tuberoso, CARLO IGNAZIO GIOVANNI; Medda, Rosaria; Pintus, Francesca BIOMED RESEARCH INTERNATIONAL
Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication 2016 Esposito, Francesca; Carli, Ilaria; Del Vecchio, Claudia; Xu, Lijia; Corona, Angela; Grandi, Nico...le; Piano, Dario; Maccioni, Elias; Distinto, Simona; Parolin, Cristina; Tramontano, Enzo PHYTOMEDICINE
Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors 2016 Corona, Angela; Desantis, Jenny; Massari, Serena; Distinto, Simona; Masaoka, Takashi; Sabatini, S...tefano; Esposito, Francesca; Manfroni, Giuseppe; Maccioni, Elias; Cecchetti, Violetta; Pannecouque, Christophe; Le Grice, Stuart F J; Tramontano, Enzo; Tabarrini, Oriana CHEMMEDCHEM
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors 2016 Schneider, Anna; Corona, Angela; Spöring, Imke; Jordan, Mareike; Buchholz, Bernd; Maccioni, Elias...; Di Santo, Roberto; Bodem, Jochen; Tramontano, Enzo; Wöhrl, Birgitta M NUCLEIC ACIDS RESEARCH
Inhibitory effect of 2,3,5,6-tetrafluoro-4-[4-(Aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide derivatives on HIV reverse transcriptase associated rnase H activities 2016 Pala, Nicolino; Esposito, Francesca; Rogolino, Dominga; Carcelli, Mauro; Sanna, Vanna; Palomba, M...ichele; Naesens, Lieve; Corona, Angela; Grandi, Nicole; Tramontano, Enzo; Sechi, Mario INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Development and identification of a novel anti-HIV-1 peptide derived by modification of the N-terminal domain of HIV-1 integrase 2016 Sala, M; Spensiero, A; Esposito, F; Scala, MC; Vernieri, E; Bertamino, A; Manfra, M; Carotenuto, ...A; Grieco, P; Novellino, E; Cadeddu, M; Tramontano, E; Schols, D; Campiglia, P; Gomez-Monterrey, IM FRONTIERS IN MICROBIOLOGY
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 2016 Corona, Angela; di Leva, Francesco Saverio; Rigogliuso, Giuseppe; Pescatori, Luca; Madia, Valenti...na Noemi; Subra, Frederic; Delelis, Olivier; Esposito, Francesca; Cadeddu, Marta; Costi, Roberta; Cosconati, Sandro; Novellino, Ettore; di Santo, Roberto; Tramontano, Enzo ANTIVIRAL RESEARCH
Onopordum illyricum L.: new anti HIV-1 agents from a Mediterranean edible plant 2015 Sanna, C; Ballero, M; Tramontano, E; Maxia, A; Maccioni, A; Marengo, A; Taglialatela-Scafati, O; ...Corona, A; Esposito, F
Kuwanon-L as a new allosteric HIV-1 integrase inhibitor: molecular modeling and biological evaluation 2015 Esposito F; Tintori C; Martini R; Christ F; Debyser Z; Ferrarese R; Cabiddu G; Corona A; Ceresola... E R; Calcaterra A; Iovine V; Botta B; Clementi M; Canducci F; Botta M; Tramontano E CHEMBIOCHEM
An efficient route to novel uracil-based drug-like molecules 2015 Babkov, Da; Chizhov, Ao; Khandazhinskaya, Al; Corona, Angela; Esposito, Francesca; Tramontano, En...zo; SELEY RADTKE, Kl; Novikov, Ms SYNTHESIS
Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans 2015 Farci, D; Bowler, MW; ESPOSITO, FRANCESCA; McSweeney, S; TRAMONTANO, ENZO; PIANO, DARIO FRONTIERS IN MICROBIOLOGY
From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors 2015 Xu, L; GRANDI, NICOLE; Del Vecchio, C; Mandas, D; CORONA, ANGELA; PIANO, DARIO; ESPOSITO, FRANCES...CA; Parolin, C; TRAMONTANO, ENZO JOURNAL OF MICROBIOLOGY
Structure-Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain 2015 Cuzzucoli Crucitti, G; Métifiot, M; Pescatori, L; Messore, A; Madia V., N; Pupo, G; Saccoliti, F;... Scipione, L; Tortorella, S; Esposito, Francesca; Corona, Angela; Cadeddu, M; Marchand, C; Pommier, Y; Tramontano, Enzo; Costi, R; Di Santo, R. JOURNAL OF MEDICINAL CHEMISTRY
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro- 1H -indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase 2015 Meleddu, Rita; Distinto, Simona; Corona, Angela; Bianco, Giulia; Cannas, Valeria; Esposito, Franc...esca; Artese, A; Alcaro, S; Matyus, P; Bogdan, D; Cottiglia, Filippo; Tramontano, Enzo; Maccioni, Elias EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments 2015 Tintori, C; Esposito, Francesca; Morreale, F; Martini, R; Tramontano, Enzo; Botta, M. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
5-arylaminouracil derivatives as potential dual-action agents 2015 Matyugina, Es; Novikov, Ms; Babkov, Da; Valuev Elliston, Vt; Vanpouille, C; Zicari, S; Corona, An...gela; Tramontano, Enzo; Margolis, Lb; Khandazhinskaya, Al; Kochetkov, Sn ACTA NATURAE
A Luciferase Reporter Gene Assay to Measure Ebola Virus Viral Protein 35–Associated Inhibition of Double-Stranded RNA–Stimulated, Retinoic Acid–Inducible Gene 1–Mediated Induction of Interferon β 2015 Cannas V; Daino GL; Corona A; Esposito F; Tramontano E THE JOURNAL OF INFECTIOUS DISEASES
ANALYSIS OF 98 HERV-K(HML-2) CONTAINING PROVIRUSES IDENTIFIED IN THE HUMAN GENOME ASSEMBLY GRCH37/HG19 BY RETROTECTOR AND THEIR GENOMIC CONTEXT 2014 CADEDDU M; N. Grandi; L. Vargiu; P. Rodriguez-Tomè; J. Blomberg; E. Tramontano
The traditional Chinese medicine plant Schisandra Chinensis as source of new HIV-1 reverse transcriptase inhibitor scaffolds effective also on non-nucleoside resistant reverse transcriptases 2014 Xu Lijia; Grandi N; Del Vecchio C; Corona A; Mandas D; Esposito F; Parolin C; Tramontano E
Identification and genomic characterization of HERV-K (HML-10) in human genome GRCh37/hg19 assembly 2014 Cadeddu M; Grandi N; Vargiu L; Rodriguez-Tomé P; Blomberg J; Tramontano E
A Homogeneous Time Resolved Fluorescence (HTRF) method for the evaluation of HIV-1 integrase dimerization, enzyme reactions and interaction with LEDGF/p75 2014 Esposito F; Enzo Tramontano
Preliminary study of endemic plants of Sardinia as a source of new antiviral agents 2014 Sanna C; Ballero M; Maxia A; Marengo A; Corona A; Tramontano E; Taglialatela-Scafati O; Esposito F
Human Endogenous Retrovirus type W distribution in the human genome: identification and characterization of a new set of proviral sequences in GRCh37/hg19 assembly 2014 Grandi N; Cadeddu M; Vargiu L; Rodriguez-Tomé P; Blomberg J; Tramontano E
New features of the cell wall of the radio-resistant bacterium Deinococcus radiodurans 2014 Farci, D; Bowler, Mw; Kirkpatrick, J; McSweeney, S; Tramontano, Enzo; Piano, Dario BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Past and future. Current drugs targeting HIV-1 integrase and reverse transcriptase-associated ribonuclease H activity: single and dual active site inhibitors 2014 Esposito F; Tramontano E ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
Can the ever-promising target HIV reverse transcriptase-associated RNase H become a success story for drug development? 2014 Corona, Angela; Esposito, Francesca; Tramontano, Enzo FUTURE VIROLOGY

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