Enzo Tramontano

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Early Diffusion of SARS-CoV-2 Infection in the Inner Area of the Italian Sardinia Island 2021 Piras, Giovanna; Grandi, Nicole; Monne, Maria; Asproni, Rosanna; Fancello, Tatiana; Fiamma, Maura...; Mameli, Giuseppe; Casu, Gavino; lo Maglio, Iana; Palmas, Angelo D.; Tramontano, Enzo FRONTIERS IN MICROBIOLOGY
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen 2021 Kuzikov, Maria; Costanzi, Elisa; Reinshagen, Jeanette; Esposito, Francesca; Vangeel, Laura; Wolf,... Markus; Ellinger, Bernhard; Claussen, Carsten; Geisslinger, Gerd; Corona, Angela; Iaconis, Daniela; Talarico, Carmine; Manelfi, Candida; Cannalire, Rolando; Rossetti, Giulia; Gossen, Jonas; Albani, Simone; Musiani, Francesco; Herzog, Katja; Ye, Yang; Giabbai, Barbara; Demitri, Nicola; Jochmans, Dirk; De Jonghe, Steven; Rymenants, Jasper; Summa, Vincenzo; Tramontano, Enzo; Beccari, Andrea R.; Leyssen, Pieter; Storici, Paola; Neyts, Johan; Gribbon, Philip; Zaliani, Andrea ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase–associated RNase H function 2021 Fois, Benedetta; Corona, Angela; Tramontano, Enzo; Distinto, Simona; Maccioni, Elias; Meleddu, Ri...ta; Caboni, Pierluigi; Floris, Costantino; Cottiglia, Filippo JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Exploring new scaffolds for the dual inhibition of HIV-1 RT polymerase and ribonuclease associated functions 2021 Meleddu, Rita; Corona, Angela; Distinto, Simona; Cottiglia, Filippo; Deplano, Serenella; Sequeira..., Lisa; Secci, Daniela; Onali, Alessia; Sanna, Erica; Esposito, Francesca; Cirone, Italo; Ortuso, Francesco; Alcaro, Stefano; Tramontano, Enzo; Mátyus, Péter; Maccioni, Elias MOLECULES
Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2 2021 Fanunza, Elisa; Carletti, Fabrizio; Quartu, Marina; Grandi, Nicole; Ermellino, Laura; Milia, Jess...ica; Corona, Angela; Capobianchi, Maria Rosaria; Ippolito, Giuseppe; Tramontano, Enzo VIRULENCE
Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata 2021 Guzzo, Francesca; Russo, Rosita; Sanna, Cinzia; Celaj, Odeta; Caredda, Alessia; Corona, Angela; T...ramontano, Enzo; Fiorentino, Antonio; Esposito, Francesca; D’Abrosca, Brigida MOLECULES
Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H 2021 Corona, Angela; Seibt, Sebastian; Schaller, David; Schobert, Rainer; Volkamer, Andrea; Biersack, ...Bernhard; Tramontano, Enzo ARCHIV DER PHARMAZIE
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase 2021 Messore, Antonella; Corona, Angela; Madia, Valentina Noemi; Saccoliti, Francesco; Tudino, Valeria...; De Leo, Alessandro; Ialongo, Davide; Scipione, Luigi; De Vita, Daniela; Amendola, Giorgio; Novellino, Ettore; Cosconati, Sandro; Métifiot, Mathieu; Andreola, Marie-Line; Esposito, Francesca; Grandi, Nicole; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto JOURNAL OF MEDICINAL CHEMISTRY
The Methanolic Extract of Perilla frutescens Robustly Restricts Ebola Virus Glycoprotein-Mediated Entry 2021 Kuo, Yu-Ting; Liu, Ching-Hsuan; Corona, Angela; Fanunza, Elisa; Tramontano, Enzo; Lin, Liang-Tzung VIRUSES
Natural and Nature-Derived Products Targeting Human Coronaviruses 2021 Vougogiannopoulou, Konstantina; Corona, Angela; Tramontano, Enzo; Alexis, Michael N.; Skaltsounis..., Alexios-Leandros MOLECULES
In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds. 2021 Sanna, C.; Marengo, A.; Acquadro, S.; Caredda, A.; Lai, R.; Corona, A.; Tramontano, E.; Rubiolo, ...P.; Esposito, F. PLANTS
Probing the importance of the g-quadruplex grooves for the activity of the anti-hiv-integrase aptamer t30923 2020 Esposito, V.; Esposito, F.; Pepe, A.; Monterrey, I. G.; Tramontano, E.; Mayol, L.; Virgilio, A.; ...Galeone, A. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Identification and characterization of ERV-W-like sequences in Platyrrhini species provides new insights into the evolutionary history of ERV-W in primates 2020 Grandi, N.; Pisano, M. P.; Demurtas, M.; Blomberg, J.; Magiorkinis, G.; Mayer, J.; Tramontano, E. MOBILE DNA
Quercetin blocks Ebola Virus infection by counteracting the VP24 Interferon inhibitory function 2020 Fanunza, Elisa; Iampietro, Mathieu; Distinto, Simona; Corona, Angela; Quartu, Marina; Maccioni, E...lias; Horvat, Branka; Tramontano, Enzo ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H 2020 Tocco, Graziella; Esposito, Francesca; Caboni, Pierluigi; Laus, Antonio; Beutler, John A.; Wilson..., Jennifer A.; Corona, Angela; Le Grice, Stuart F. J.; Tramontano, Enzo JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity 2020 Desantis, Jenny; Massari, Serena; Corona, Angela; Astolfi, Andrea; Sabatini, Stefano; Manfroni, G...iuseppe; Palazzotti, Deborah; Cecchetti, Violetta; Pannecouque, Christophe; Tramontano, Enzo; Tabarrini, Oriana MOLECULES
Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition 2020 Hayek, S.; Pietrancosta, N.; Hovhannisyan, A. A.; Alves de Sousa, R.; Bekaddour, N.; Ermellino, L....; Tramontano, E.; Arnould, S.; Sardet, C.; Dairou, J.; Diaz, O.; Lotteau, V.; Nisole, S.; Melikyan, G.; Herbeuval, J. -P.; Vidalain, P. -O. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Contribution of human retroviruses to disease development-A focus on the HIV- And HERV-cancer relationships and treatment strategies 2020 Liu, C. -H.; Grandi, N.; Palanivelu, L.; Tramontano, E.; Lin, L. -T. VIRUSES
A human MMTV-like betaretrovirus linked to breast cancer has been present in humans at least since the Copper Age 2020 Lessi, F.; Grandi, N.; Mazzanti, C. M.; Civita, P.; Scatena, C.; Aretini, P.; Bandiera, P.; Forna...ciari, A.; Giuffra, V.; Fornaciari, G.; Naccarato, A. G.; Tramontano, E.; Bevilacqua, G. AGING
Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants 2020 Corona, Angela; Ballana, Ester; Distinto, Simona; Rogolino, Dominga; Del Vecchio, Claudia; Carcel...li, Mauro; Badia, Roger; Riveira-Muñoz, Eva; Esposito, Francesca; Parolin, Cristina; Esté, José A; Grandi, Nicole; Tramontano, Enzo VIRUSES
RNA-seq transcriptome analysis reveals long terminal repeat retrotransposon modulation in human peripheral blood mononuclear cells after in vivo lipopolysaccharide injection 2020 Pisano, M. P.; Tabone, O.; Bodinier, M.; Grandi, N.; Textoris, J.; Mallet, F.; Tramontano, E. JOURNAL OF VIROLOGY
Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture 2020 Pala, Nicolino; Esposito, Francesca; Tramontano, Enzo; Kumar Singh, Pankaj; Sanna, Vanna; Carcell...i, Mauro; Haigh, Lisa D.; Satta, Sandro; Mario Sechi, And ACS MEDICINAL CHEMISTRY LETTERS
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase 2020 Messore, Antonella; Corona, Angela; Madia, Valentina Noemi; Saccoliti, Francesco; Tudino, Valeria...; De Leo, Alessandro; Scipione, Luigi; De Vita, Daniela; Amendola, Giorgio; Di Maro, Salvatore; Novellino, Ettore; Cosconati, Sandro; Métifiot, Mathieu; Andreola, Marie-Line; Valenti, Piera; Esposito, Francesca; Grandi, Nicole; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto ACS MEDICINAL CHEMISTRY LETTERS
Peptides Mimicking the β7/β8 loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors 2020 Sánchez-Murcia, Pedro A.; de Castro, Sonia; García-Aparicio, Carlos; Jimenez, M. Angeles; Corona,... Angela; Tramontano, Enzo; Sluis-Cremer, Nicolas; Menendez Arias, Luis; Velazquez, Sonsoles; Gago, Federico; Camarasa, María-José ACS MEDICINAL CHEMISTRY LETTERS
Comprehensive Analysis of HERV Transcriptome in HIV+ Cells: Absence of HML2 Activation and General Downregulation of Individual HERV Loci 2020 Grandi, Nicole; Pisano, Maria Paola; Scognamiglio, Sante; Pessiu, Eleonora; Tramontano, Enzo VIRUSES
High-Throughput Sequencing is a Crucial Tool to Investigate the Contribution of Human Endogenous Retroviruses (HERVs) to Human Biology and Development 2020 Pisano, Maria Paola; Grandi, Nicole; Tramontano, Enzo VIRUSES
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors 2020 Esposito, Francesca; Sechi, Mario; Pala, Nicolino; Sanna, Adele; Koneru, Pratibha Chowdary; Kvara...tskhelia, Mamuka; Naesens, Lieve; Corona, Angela; Grandi, Nicole; di Santo, Roberto; D'Amore, Vincenzo Maria; Di Leva, Francesco Saverio; Novellino, Ettore; Cosconati, Sandro; Tramontano, Enzo ANTIVIRAL RESEARCH
2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication 2020 Corona, Angela; Onnis, Valentina; Del Vecchio, Claudia; Esposito, Francesca; Cheng, Yung-Chi; Tra...montano, Enzo MOLECULES
Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus 2019 Tramontano, Enzo; Corona, Angela; Menendez-Arias, Luis ANTIVIRAL RESEARCH
Comprehensive Characterization of the Human Endogenous Retrovirus HERV-K(HML-6) Group: Overview of Structure, Phylogeny, and Contribution to the Human Genome 2019 Pisano, Maria Paola; Grandi, Nicole; Cadeddu, Marta; Blomberg, Jonas; Tramontano, Enzo JOURNAL OF VIROLOGY
Meeting report: 32nd International Conference on Antiviral Research 2019 Tramontano, E.; Tarbet, B.; Spengler, J. R.; Seley-Radtke, K.; Meier, C.; Jordan, R.; Janeba, Z.;... Gowen, B.; Gentry, B.; Este, J. A.; Bray, M.; Andrei, G.; Schang, L. M. ANTIVIRAL RESEARCH
Intracellular human antibody fragments recognizing the VP35 protein of Zaire Ebola filovirus inhibit the protein activity 2019 Flego, M.; Frau, A.; Accardi, L.; Mallano, A.; Ascione, A.; Gellini, M.; Fanunza, E.; Vella, S.; ...Di Bonito, P.; Tramontano, E. BMC BIOTECHNOLOGY
Insights into Ebola Virus VP35 and VP24 Interferon inhibitory functions and their initial exploitation as drug targets 2019 Fanunza, Elisa; Frau, Aldo; Corona, Angela; Tramontano, Enzo INFECTIOUS DISORDERS - DRUG TARGETS
Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy) 2019 SANNA, CINZIA; Rigano, Daniela; CORONA, ANGELA; PIANO, DARIO; Formisano, Carmen; FARCI, DOMENICA;... Franzini, Genni; BALLERO, MAURO; Chianese, Giuseppina; TRAMONTANO, ENZO; Taglialatela-Scafati, Orazio; ESPOSITO, FRANCESCA NATURAL PRODUCT RESEARCH
Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques 2019 Costa, Giosuè; Rocca, Roberta; Corona, Angela; Grandi, Nicole; Moraca, Federica; Romeo, Isabella;... Talarico, Carmine; Giovanna Gagliardi, Maria; Alessandra Ambrosio, Francesca; Ortuso, Francesco; Alcaro, Stefano; Distinto, Simona; Maccioni, Elias; Tramontano, Enzo; Artese, Anna EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors 2019 Massari, Serena; Corona, Angela; Distinto, Simona; Desantis, Jenny; Caredda, Alessia; Sabatini, S...tefano; Manfroni, Giuseppe; Felicetti, Tommaso; Cecchetti, Violetta; Pannecouque, Christophe; Maccioni, Elias; Tramontano, Enzo; Tabarrini, Oriana JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity 2019 Esposito, F.; Ambrosio, F. A.; Maleddu, R.; Costa, G.; Rocca, R.; Maccioni, E.; Catalano, R.; Rom...eo, I.; Eleftheriou, P.; Karia, D. C.; Tsirides, P.; Godvani, N.; Pandya, H.; Corona, A.; Alcaro, S.; Artese, A.; Geronikaki, A.; Tramontano, E. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
The emerging field of human endogenous retroviruses: Understanding their physiological role and contribution to diseases 2019 Grandi, N.; Pisano, M. P.; Tramontano, E. FUTURE VIROLOGY
Relevance of Ebola virus VP35 homo-dimerization on the type I interferon cascade inhibition 2019 Di Palma, Francesco; Daino, Gian Luca; Ramaswamy, Venkata Krishnan; Corona, Angela; Frau, Aldo; F...anunza, Elisa; Vargiu, Attilio V; Tramontano, Enzo; Ruggerone, Paolo ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
Meeting report: Fourth Summer School on Innovative Approaches for Identification of Antiviral Agents (IAAASS) 2019 Le Grice, Stuart; Maccioni, Elias; Corona, Angela; Parolin, Cristina; Tramontano, Enzo ANTIVIRAL RESEARCH
Insights into Ebola VP35 oligomerization from molecular simulations 2018 DI PALMA, Francesco; Ramaswamy, VENKATA KRISHNAN; Daino, Gianluca; Frau, Aldo; Corona, Angela; Zi...nzula, Luca; Tramontano, Enzo; Ruggerone, Paolo; Vargiu, ATTILIO VITTORIO ABSTRACTS OF PAPERS - AMERICAN CHEMICAL SOCIETY AMER CHEMICAL SOC
Antiviral Agents Against Ebola Virus Infection: Repositioning Old Drugs and Finding Novel Small Molecules 2018 Fanunza, Elisa; Frau, Aldo; Corona, Angela; Tramontano, Enzo ANNUAL REPORTS IN MEDICINAL CHEMISTRY
Use of a Dual Luciferase Cell-Based Drug Screening Assay to Study VP24 Inhibition of JAK/STAT Pathway and its Reversion by Compounds 2018 Fanunza, Elisa; Frau, Aldo; Sgarbanti, Marco; Orsatti, Roberto; Corona, Angela; Tramontano, Enzo
Development and validation of a novel dual luciferase reporter gene assay to quantify Ebola virus VP24 inhibition of IFN signaling 2018 Fanunza, Elisa; Frau, Aldo; Sgarbanti, Marco; Orsatti, Roberto; Corona, Angela; Tramontano, Enzo VIRUSES
On the S-layer of Thermus thermophilus and the assembling of its main protein SIpA 2018 Farci, Domenica; Farci, Stefano Francesco; Esposito, Francesca; Tramontano, Enzo; Kirkpatrick, Jo...anna; Piano, Dario BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops 2018 Virgilio, Antonella; Amato, Teresa; Petraccone, Luigi; Esposito, Francesca; Grandi, Nicole; Tramo...ntano, Enzo; Romero, Raquel; Haider, Shozeb; Gomez-Monterrey, Isabel; Novellino, Ettore; Mayol, Luciano; Esposito, Veronica; Galeone, Aldo SCIENTIFIC REPORTS
Uvaria angolensis as a promising source of inhibitors of HIV-1 RT-associated RNA-dependent DNA polymerase and RNase H functions 2018 NGOUTANE MFOPA, Alvine; Corona, Angela; Eloh, Kodjo; Tramontano, Enzo; Frau, Aldo; Boyom, Fabrice... Fekam; Caboni, Pierluigi; Tocco, Graziella NATURAL PRODUCT RESEARCH
HERV envelope proteins: Physiological role and pathogenic potential in cancer and autoimmunity 2018 Grandi, Nicole; Tramontano, Enzo FRONTIERS IN MICROBIOLOGY
Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication 2018 Sanna, Cinzia; Scognamiglio, Monica; Fiorentino, Antonio; Corona, Angela; Graziani, Vittoria; Car...edda, Alessia; Cortis, Pierluigi; Montisci, Mariofilippo; Rita Ceresola, Elisa; Canducci, Filippo; Poli, Ferruccio; Tramontano, Enzo; Esposito, Francesca PLOS ONE
HERV-W group evolutionary history in non-human primates: Characterization of ERV-W orthologs in Catarrhini and related ERV groups in Platyrrhini 2018 Grandi, Nicole; Cadeddu, Marta; Blomberg, Jonas; Mayer, Jens; Tramontano, Enzo BMC EVOLUTIONARY BIOLOGY

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