IA/0152/EN - BIOSENSORS AND BIOELECTRONICS
Academic Year 2022/2023
Free text for the University
STEFANO LAI (Tit.)
- Teaching style
- Lingua Insegnamento
|[70/83] ELECTRONIC ENGINEERING||[83/25 - Ord. 2018] ELECTRONIC TECHNOLOGIES FOR EMERGING APPLICATIONS||6||60|
The course will provide to students a general introduction to the principal application fields of bioelectronics, with a particular focus on theoretical and pratical aspects in biosensor design. The main characteristics of biointerfaces, where interaction between biological matter and inorganic materials take place, will be discussed. Transduction strategies for biochemical signals and biopotential will be analized. State-of-the-art and the most up-to-date trends in literature about biosensor technologies and applications will be deepened.
-Acquiring knowledge and understanding: the student will learn fundamental concepts, technologies and issues related to the development of bioelectronic applications;
-Appying knowledge and understanding: the student will be able to apply the foreground on bioelectronics, biointerfaces and electronic devices for the analysis and design of bioelectronic and biosensor systems;
-Making informed judgements and choices: the student will be able to understand data and plots related to bioelectronic applications, deriving information about properties of biointerfaces, biosensors and biopotentials, evaluating performances and, if necessary, defining strategies for performance improvement and optimization;
- Communicating knowledge and understanding: the student will be able to report about the foreground using appropriate technical terms, and to use appropriate metrics to describe performances of considered applications:
- Capacities to continue learning: the student will be able to integrate the concepts related to different fields physics, chemistry, biology and electronics for the design and analysis of bioelectronic systems; the student will be also able to integrate the concepts provided during lessons with the most up-to-date results reported in literature.
Basic concept of physics, physic of the solid matter, chemistry and electronic devices are fundamental prerequisites. A basic knowledge of softwares for data elaboration and presentation is preferential.
- Introduction: bioelectronics and its applications.
- Basics on chemistry: chemical elements, compounds and molecules; chemical reactions and kinetics.
- Introduction to biosensors: main features and technologies.
- The measurement environment in biosensing: features of biofluids; the chemistry of water, acids, bases and pH; buffer solutions; electrostatic interaction in liquid environment;
- Biomolecules: classifications (lipids, carbohydrates, peptieds, nucleic acids) and their biochemical and electrical properties;
- Bioeceptor layer: properties of the surfaces, approaches to surface adsorption (physical, chemical, entrapment of biomolecules); Langmuir-Blodgett Films and Self-Assembled Monolayers;
- Principles of kinetics for biochemical reactions.
- Biosensors: classifications on transduction principle and their application in biomolecular recognition. Analysis of the main technologies for biosensing. Analysis of transduction principles (optical, mechanical, electrochemical and electronic biosensors); introduction to readout circuits for biosensors.
- Cells and biopotentials: the cell membrane and ionic transport through cell memberane; action potentials and its propagation; recording of action potentials; from action potential to biopotentials (ECG, EMG, EEG, ENG, EOG).
- Acquisition of biopotentials: electrodes for biopotential recordings; biopotential amplifiers.
The main part of the course will be organized in theoretical lectures. Practical activities will be carried out in class at the end of each module. During these activities, students will be divided into small groups and they will be asked to solve tests about the theory discussed during the lectures. These practical activities will be partially supervised in class, and will be completed autonomously by students. They will be mandatory, and a final report must be provided by students.
In observance of possible limitations related to the epidemiologic situation, lessons and classroom exercizes could be provided with different modalities (recordings or live streaming) through available platforms.
Verification of learning
Two modalities are foreseen:
- project + oral on part of the program (defined by the teacher);
- oral on the whole program of the course
- Florinel-Gabriel Banica, "Chemical Sensors and Biosensors - fundamentals and applications" - Wiley ED.
-Pethig, R. R., & Smith, S. (2012). Introductory Bioelectronics: For Engineers and Physical Scientists. John Wiley & Sons.
- Webster, John G. (Ed.), “Medical instrumentation: application and design”, John Wiley & Sons, 2009
Slides employed during lessons will be provided as a support for study. Basic concept provided in the course will be integrated with the most up-to-date publications in the field of bioelectronics.