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Second Semester 
Teaching style
Lingua Insegnamento

Informazioni aggiuntive

Course Curriculum CFU Length(h)


The aim of this course is to provide the basic knowledge concerning the functional mechanisms of human body systems and apparatus in maintaining the internal environment constancy.
The student must acquire knowledge needed to understand the physiopathological processes.


Basic knowledge of histology, genetics and biology.


General organization of the CNS and PNS; genesis, management and propagation of neuronal action potential, ANS.
Endocrine system: general characteristics of the endocrine system, hormone classes, mechanisms of action of protein and steroid hormones.
Contractile apparatus: structure of the striated muscle, neuromuscular junction. Mechanism of contraction. Smooth Muscle.
Cardiovascular system: the heart, nodal tissue, the genesis of the heartbeat (potential nodal), the action potential of myocardium, the cardiac cycle, regulation of cycle cardiac, morphological and functional characteristics of the blood vessels, capillary exchange.
Respiratory system: general structure, functions of the conduction zone, the alveoli and gas exchange. Respiratory mechanics. and control of breathing.
Urinary system: structure and function of the kidney. Cortical and juxtamedullary nephrons, sodium and water reabsorption along the tubular structure, the role of the juxtaglomerular apparatus. Renal clearance. Body fluid balance.

General Pathology:
Introduction to Pathology
Difference between physiologic and pathologic; elements characterizing a pathological process: eziology,pathogenesis, morphological modifications, clinical outcome.
Adaption of cell to stress
Ipertrophy, iperplasia, atrophy and metaplasia.
Cell damage
General biochemical mechanisms, reversible and irreversible damage.
Cell death
Necrosis (coagulative and colliquative necrosis) and apoptosis (extrinsic and intrinsic)
Acute inflammation
Vascular modifications (vascular permeability and edema, mediators of increased permeability in inflammatory edema, adhesion molecules), cellular recruitment (inflammatory cell activation, mechanisms of inflammatory cell functions, Outcomes of inflammation, cellular and plasmatic mediators of inflammation.
Tissue repair
Cell cycle regulation; regeneration and fibrosis
Oncogenes and tumor suppressor genes
Benign and malignant tumors (classification, morphological, biochemical and behavioral characteristics, angiogenesis, local invasion, metastatic process)

Teaching Methods

Methods and techniques of interactive teaching in the presence of the teacher.
Dialogue in the classroom proposed by the teacher.
Combination of interactive and classroom teaching with the application of tools and of a variety of media in the classroom (video projections and blackboard).
Teacher-student interaction: communication by e-mail.
Content condivision: pdf of the lectures.

Verification of learning

Physiology: Oral examination.
General Pathology: Final test in the form of quiz; test failure will require oral re-examination.
Final score will be determined by the arithmetic mean of the single scores.
Registration for the exam will be done online through the ESSE 3 platform.
Dates for oral examinations will be chosen within the periods determined by the Faculty schedule.


1) Fisiologia Umana Approccio integrato- Silverthorn – Pearson editore
2) Compendio di fisiologia umana per i corsi di laurea in professioni sanitarie –MIDRIO AZZENA- PICCIN

General Pathology: Robbins e Cotran. Le basi patologiche delle malattie. Patologia Generale.

More Information

Teaching Language: Italian

Contact addresses:
1. Pibiri Monica: Department of Biomedical Science, Section of Pathology, Oncology and Molecular Pathology Unit,
Cittadella Universitaria di Monserrato.
Blocco A
Tel.: 070/675-8637 fax: 070/666062

2. Romina Vargiu: Department of Biomedical Science, Section of Physiology, Cittadella Universitaria di Monserrato.
Tel.070 6753907

Questionnaire and social

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