Teachings

Select Academic Year:     2017/2018 2018/2019 2019/2020 2020/2021 2021/2022 2022/2023
Professor
PAOLA FADDA (Tit.)
LUCA PILLONI
AMEDEO COLUMBANO
Period
First Semester 
Teaching style
Convenzionale 
Lingua Insegnamento
 



Informazioni aggiuntive

Course Curriculum CFU Length(h)
[40/42]  NURSING [42/00 - Ord. 2016]  PERCORSO COMUNE 9 72

Objectives

The course aims to provide the students with the basic knowledge of Immunology, Pathology, Pathophysiology, Clinical Pathology, Pathological Anatomy and Pharmacology. The student will learn basic concepts and basic technical knowledge of innate and adaptive immune response, basic mechanisms for the development of diseases, the main functional and pathological alterations affecting the different organs and systems.
He/she will also learn the main effects of drugs on these pathophysiological mechanisms and will be able to evaluate their effects on the patient, including any adverse effects.

Knowledge and understanding. Students will acquire basic knowledge on main physiopathological processes. The student will learn how different aspects of physiopathology are integrated in the functional unit of a single biological entity, i.e. the body.
Students will acquire basic knowledge on cytopathology, histopathology and anatomo-clinical correlates of main disease processes, both at macro- and micro-scopic level.
At the end of the course, the student will be able to understand that medications implement their effects by interacting with the living matter, the rules governing these interactions, and the mechanisms whereby drugs reach their site of action and induce both favorable and adverse effects.
Applying knowledge and understanding. The knowledge of basic physiopathological processes and the comprehension of their biological significance will allow the student to properly apply the information in the context of his/her professional activity.
The knowledge of basic cytopathology, histopathology and anatomo-clinical correlates and an understanding of their biological significance will allow the student to apply the information accordingly in the context of his/her professional activity.
The student will acquire the ability to perform an evaluation of proper drug therapy and to predict the possible side effects.
Making judgments. Based on the acquired knowledge on the concept of disease and basic disease processes, the student will be able to evaluate and operate responsibly during his/her professional activity, within the established limits of his/her role.
Based on the acquired knowledge on cytopathology, histopathology and anatomo-clinical correlates, the student will be able to evaluate and operate responsibly during his/her professional activity, within the established limits of his/her role.
He/she will be able to monitor the selection and administration of a drug therapy, to evaluate patient compliance, possible adverse effects, and to understand the strategies to reduce negative consequences.
Communication skills. The student will be able to communicate the knowledge acquired by using the most appropriate terminology for any specific professional context. This ability will help the interaction with the patients, their families and the other health professionals.
Learning ability. The student will develop skills for an independent study, and the notion that his/her profession will require a continuous update of scientific literature. The student will, therefore, learn how to gather relevant information in order to fulfill this requirement.

Prerequisites

Knowledge of Anatomy, biology, physic, biochemical, physiology and prerequisites as provided for in the in Degree regulation

Contents

Morbid Anatomy:
Description of the main tools of the laboratory of Pathology.
How to send biopsies for histological examination.
Specimens preparation techniques:
fixation and processing,
inclusion and cutting,
routine staining.
Special techniques:
histochemistry and immunohistochemistry.
Description of a pathology model

General and Clinical Pharmacology and Pharmacovigilance:
Pharmacokinetic: Routes of administration. Transport across biological barriers. Distribution and protein binding. Biotransformation and bioactivation. Extrarenal and renal excretion of drugs. Pharmacokinetic parameters: bioavailability, apparent volume of distribution; plasma half-life; clearance.
Pharmacodynamic: Mechanisms of action of receptors. Receptor mechanisms of action: receptor sites, endogenous ligands. Concentration-response curves; agonists, partial agonists, inverse agonists. Adverse reactions and tolerance to drugs
Clinical pharmacology: quantal dose-response curves. Therapeutic index. Individual differences in response to drugs. Mechanisms of drug interaction: physical-chemical, pharmacokinetic, pharmacodynamic, functional interaction. Placebo effect, homeopathy and "alternative" medicine. Elements of pharmacoeconomic. Principles of pharmacovigilance.
Special pharmacology:
Pharmacology of the autonomic nervous system
Antidepressants, antipsychotics, sedative-anxiolytic.
Addiction.
Opioid and non-opioid analgesics.
Non-steroidal Anti-inflammatory drugs (NSAID) and other antipyretic / analgesic drugs.
Steroidal anti-inflammatory drugs.
Cardiovascular drugs.
Drugs used in hyperlipoproteinemias, anticoagulants, antithrombotics, anti-platelets.
Drugs used in the treatment of gastroduodenal ulcer and gastrointestinal motility.
Estrogens, progestins, androgens, insulin and oral hypoglycemic agents, antithyroid drugs.
Antibiotics and chemotherapeutics.
Principles of toxicology and drug interactions.

General Pathology, Immunology, Physiopatology and Clinical Pathology:
Concept of disease
Cellular adaptations
Cell death
Acute and chronic inflammatory process: biology and mediators - Phagocytosis
Complement, Coagulation and inflammation
Systemic signs of inflammation
Innate and acquired immunity
Specific immune response: B and T-lymphocytes
Hypersensitivity reactions
Active and passive immunoprophylaxis
Immunodeficiencies
Autoimmunity
Genetic bases of disease
Biology of neoplasia
Etiology and pathogenesis of neoplasia
Metastases
Homeostasis of oxygen and nutrients supply
Physiopatology of respiratory, circulatory, gastrointestinal, endocrine and hematological systems.
Elements of Pathophysiology of hemostasis: hemorrhagic syndromes, thrombosis
Elements of Pathophysiology of metabolism: diabetes mellitus, dyslipidemia
Main tumor markers: sensitivity, specificity, proper use
Examination and blood count interpretation, the PT and PTT
Enzymes of necrosis in the diagnosis of organ damage
Clinical laboratory measurement of renal function
Laboratory monitoring of diabetes mellitus

Teaching Methods

Interactive frontal learning, lecture-style.

Texts

Anatomia Patologica:
- - Anatomia Patologica. Le basi. - L. Ruco e A. Scarpa. Edizioni UTET.
- Nozioni di tecniche diagnostiche di Anatomia Patologica. Maria Rosaria Cardillo. Antonio Delfino Editore medicina-scienze
- Le Basi Patologiche Delle Malattie 8ed 2vol. - Robbins e Cotran. Elsevier
- Atlante di Anatomia Patologica. - Robbins e Cotran. Edra S.p.A. (pubblicata in accordo con Elsevier Inc.)
- G.M. Mariuzzi. Anatomia Patologica e Correlazioni Anatomo-Cliniche 2 vol. Piccin Nuova Libraria S.p.A.
- Tecniche in Anatomia Patologica. Marco Melis, Francesco Carpino, Ugo Di Tondo. Edizioni: EDI-ERMES
- Manuale di Tecnica Cito-Istologica. Sergio Daniel, Tiziano Zanin - Documentazione Scientifica Editrice (DSE)- Bologna


Farmacologia:
Amico-Roxas, Caputi, Del Tacca. Compendio di farmacologia generale e speciale. Utet, 2005.
A. Conforti, L. Cuzzolin, R. Leone, U. Moretti, G. Pignataro, M. Tagliatela, M. Vanzetta
Farmacologia per le professioni sanitarie SORBONA
Howland, Mycek. Le basi della farmacologia. Zanichelli, 2007
Pharmacology:
Amico-Roxas, Caputi, Del Tacca. Compendio di farmacologia generale e speciale. Utet, 2005.
A. Conforti, L. Cuzzolin, R. Leone, U. Moretti, G. Pignataro, M. Tagliatela, M. Vanzetta
Farmacologia per le professioni sanitarie SORBONA
Howland, Mycek. Le basi della farmacologia. Zanichelli, 2007

Patologia, Fisiopatologia e Patologia Clinica
Testi di Patologia e Fisiopatologia per le Lauree sanitarie presenti presso la Biblioteca di Ateneo

More Information

Faculty Office hours
by appointment: location and time will be set in advance via email
Morbid Anatomy:
Pilloni Luca email lucpilloni@tiscali.it
General and Clinical Pharmacology and Pharmacovigilance
Paola Fadda email: pfadda@unica.it@unica.it
General Pathology, Immunology, Physiopatology and Clinical Pathology:
Columbano Amedeo email: columban@unica.it

Questionnaire and social

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