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First Semester 
Teaching style
Lingua Insegnamento

Informazioni aggiuntive

Course Curriculum CFU Length(h)
[40/39]  MEDICINE AND SURGERY [39/00 - Ord. 2015]  PERCORSO COMUNE 11 110


The essential aim of the Course of Pathology and Pathophysiology is to define the concept of disease and to identify the etiologic factors and underlying mechanisms through which these act by establishing a direct link between the basic and clinical disciplines. This should enable the student to establish causal relationships between etiological factors and specific diseases.
The program includes, in particular, the discussion of genetic diseases, the causes of illness by physical, chemical and biological agents, the mechanisms of cell death, the inflammatory process, the neoplastic development, metabolism disturbances and basic pathophysiological processes in the various organs and systems.


The student must be acquainted with fundamental notions of Cell Biology, Biochemistry and Péhysiology


General Pathology: Cellular stress and mechanism of adaptation, cell injury and cell death ( necrosis and apoptosis) -Acute and chronic inflammation - Repair, regeneration and fibrosis - Cell proliferation and differentiation-Molecular bases of genetic diseases: Point mutations, frameshift mutations) – Genetic diseases: autosomal dominant, recessive and related to X.- Chromosome abnormalities) - Causes of diseases: injuries from physical agents (radiation). Biotransformation of endogenous and exogenous agents. Environmental and occupational disease, smoking, alcohol, chemically-induced injury. Ageing.
-Oncology: Principles of cancer epidemiology, Definition and Terminology. Characteristics of benign and malignant tumors - Metastasis- Atypia - Etiologic agents: chemicals. physical and viral - Mechanism of action of carcinogens and DNA repair systems - Molecular basis of cancer - Biology of tumor growth – Principles of targeted therapy - Models of carcinogenesis –
Pathophysiology: Thermoregulation _ Hyperthermia and fever. Diabetes. Gout. Atherosclerosis, thrombosis, embolism. Liver steatosis, AFLD and NAFLD. Heart failure and hypertension. Pathogenesis of the main respiratory diseases and respiratory failure. Qualitative and quantitative alterations of blood cells. Non-inflammatory edema. Osteoporosis. Obesity and malnutrition. Altered production, transmission, reception and signal transduction of hormones.

Teaching Methods

Lectures (In Italian)

Verification of learning

Written and oral
N.3 written self-evaluation tests (November, February, April)
At the end of the course the student is required to pass an oral exam
To pass the exam, the student must report a score equal or higher than 18/30


R. S. Cotran, V. Kumar, S. L. Robbins (Pathological Basis of Disease);
Pontieri (Patologia Generale);
Stevens & Lowe (Patology)
Prof. Atzori: lezioni su Moodle

More Information


Columbano A, Atzori L: Sezione di Oncologia e Patologia Molecolare (Dipartimento di Scienze Biomediche), Via Porcell 4, 1° floor, Tel. 070-675 8346

Laconi E, Batetta B: Sezione di Patologia Sperimentale (Dipartimento di Scienze Biomediche), Via Porcell 4, 2° Floor, Tel. 070-675 8682; 070-675 8343

All lecturers of the course can be contacted for appointment via e-mail, phone, every day
Prof.Luigi Atzori can also be contacted by phone at the following number: 070-6758390)

Questionnaire and social

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