Neuropsychological characterization of aggressive behavior in children and adolescents with cd/odd and effects of single doses of medications: The protocol of the matrics_wp6-1 study

Balia C.
;
Carucci S.
;
Milone A.;Romaniello R.;Donno F.;Masi G.;Zuddas A.
2021

Abstract

Aggressive behaviors and disruptive/conduct disorders are some of the commonest reasons for referral to youth mental health services; nevertheless, the efficacy of therapeutic interventions in real-world clinical practice remains unclear. In order to define more appropriate targets for innovative pharmacological therapies for disruptive/conduct disorders, the European Commission within the Seventh Framework Programme (FP7) funded the MATRICS project (Multidisciplinary Approaches to Translational Research in Conduct Syndromes) to identify neural, genetic, and molecular factors underpinning the pathogenesis of aggression/antisocial behavior in preclinical models and clinical samples. Within the program, a multicentre case-control study, followed by a single-blind, placebo-controlled, cross-over, randomized acute single-dose medication challenge, was conducted at two Italian sites. Aggressive children and adolescents with conduct disorder (CD) or oppositional defiant disorder (ODD) were compared to the same age (10–17 y) typically developing controls (TDC) on a neuropsychological tasks battery that included both “cold” (e.g., inhibitory control, decision making) and “hot” executive functions (e.g., moral judgment, emotion processing, risk assessment). Selected autonomic measures (heart rate variability, skin conductance, salivary cortisol) were recorded before/during/after neuropsychological testing sessions. The acute response to different drugs (methylphenidate/atomoxetine, risperidone/aripiprazole, or placebo) was also examined in the ODD/CD cohort in order to identify potential neuropsychological/physiological mechanisms underlying aggression. The paper describes the protocol of the clinical MATRICS WP6-1 study, its rationale, the specific outcome measures, and their implications for a precision medicine approach.
2021
Inglese
11
12
1639
1
20
20
Esperti anonimi
internazionale
scientifica
aggression; conduct disorder; oppositional defiant disorder; medications for aggression; callous-unemotional traits; D2 receptor modulators; ADHD medications; neuropsychological functioning; autonomic functioning; control design; acute placebo-controlled single-blind challenge clinical trial
Balia, C.; Carucci, S.; Milone, A.; Romaniello, R.; Valente, E.; Donno, F.; Montesanto, A.; Brovedani, P.; Masi, G.; Glennon, J. C.; Coghill, D.; Zuddas, A.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
12
open
Files in This Item:
File Size Format  
brainsci Balia 2021 Matrics protocol.pdf

open access

Type: Complete doctoral thesis
Size 282 kB
Format Adobe PDF
282 kB Adobe PDF View/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Questionnaire and social

Share on:
Impostazioni cookie