Zinc and other metals deficiencies and risk of type 1 diabetes: an ecological study in the high risk Sardinia island

VALERA, PAOLO;ZAVATTARI, PATRIZIA;SANNA, ALESSANDRO;
2015

Abstract

Type 1 diabetes incidence presents a decreasing gradient in Europe from the Nordic countries to the Mediterranean ones. Exception to this gradient is represented by Sardinia, the second largest Mediterranean island whose population shows the highest incidence in Europe, after Finland. The genetic features of this population have created a fertile ground for the epidemic of the disease, however, as well as being strikingly high, the incidence rate has suddenly presented a continuous increase from the '50s, not explainable by accumulation of new genetic variants. Several environmental factors have been taken into account, possibly interacting with the genetic/epigenetic scenario, but there are no strong evidences to date.
Inglese
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15
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141262
Esperti anonimi
internazionale
scientifica
no
Valera, Paolo; Zavattari, Patrizia; Sanna, Alessandro; Pretti, S; Marcello, A; Mannu, C; Targhetta, C; Bruno, G; Songini, M.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
9
open
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