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Professor
ALBERTO CINCOTTI (Tit.)
Period
Second Semester 
Teaching style
Convenzionale 
Lingua Insegnamento
ITALIANO 



Informazioni aggiuntive

Course Curriculum CFU Length(h)
[70/75]  BIOMEDICAL ENGINEERING [75/00 - Ord. 2017]  PERCORSO COMUNE 5 50

Objectives

Knowledge of application of transport phenomena, phase and chemical equilibrium, and prime principle of conservation to biomedical processes and systems like the design or testing of extra-corporeal apparatuses and kinetics involved in biomedical devices.
Understanding the influence of operating conditions and contacting systems between phases in biomedical devices, and how to take them into account during design or testing.

Prerequisites

Chmistry. Mathematical Analysis. Transport phenomena in biomedical and living systems. Chemical and Biological kinetics. Thermodynamics.

Contents

Physico-chemical and biological phenomena (Material balances at steady-state and transient conditions, fluid-dynamics of perfect-mixing and plug-flow, chemical and phase equilibria, chemical and biological reaction kinetics). Pharmacokinetics (definition of clearance, mono- and bi-compartimental models, determination of adjustable model parameters), Extra-corporeal devices: dyalizer, immobilized enzyme reactors (CSTR and PFR) Oxygenators (Henry and Hill laws)

Teaching Methods

Lessons 30 hours.
Exercises 20 hurs.
Lectures will be prevalently held in classrooms, also integrated with online teaching resources, by using specific online platforms
managed by the University of Cagliari

Verification of learning

Student attendance to course activities is mandatory. The final examination consists of a written exam with questions on the academic program analyzed in class. The student will be asked to demonstrate his capability on every topic addressed during the lessons and exercises in class: write down the mathematical equations describing the system, with the required modeling details (i.e. balancing the level description of the different phenomena involved in a proper way), but also to extend to more complex description when a more detailed simulation is needed; the student will be asked to know and apply the simplifying assumptions typically adopted in a deterministic modeling of biomedical processes, devices and apparatuses, to properly communicate the design options and test results.

Texts

G.A. Truskey, F. Yuan, D.F. Katz, Transport phenomena in biological systems, Pearson Prentice Hall, (2004).
D.O. Cooney, Biomedical Engineering Principles, An introduction to fluid, heat, and mass transport processes, Marcel Dekker, Inc., (1976).
R.L. Fournier, Basic Transport Phenomena in Biomedical Engineering, Taylor and Francis, (1999).
R.E. Notari, Biofarmaceutica e Farmacocinetica, Piccin Editore Padova, (1981).
Lecture notes provided by instructor.

Questionnaire and social

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