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Professor
MARIANGELA SERRA (Tit.)
Period
Second Semester 
Teaching style
Convenzionale 
Lingua Insegnamento
 



Informazioni aggiuntive

Course Curriculum CFU Length(h)
[60/57]  BIOLOGY [57/00 - Ord. 2018]  PERCORSO COMUNE 7 60

Objectives

The aim of the course is to provide students with the basics of General Pharmacology, starting from the principles of pharmacokinetics and pharmacodynamics, and to illustrate the effects of the major classes of drugs, at the cellular level and at organs and systems. The course will also highlight the importance of drugs as research tools for understanding the cellular and molecular mechanisms underlying the physiological processes. The above objectives will be pursued through lectures and laboratory classes.

KNOWLEDGE AND UNDERSTANDING: The student will gain knowledge of the principles of General Pharmacology acquiring the concept of drugs as tools for the study of cell function through its interaction with the molecular target. He will also acquire the knowledge on the effects and mechanisms of action of the different classes of drugs. The student will also acquire knowledge about the concept of addiction and the effects of various drugs of abuse.
APPLYING KNOWLEDGE AND UNDERSTANDING: The course provides students with the necessary bases useful to better understand and apply the concepts given by the disciplines learned from this and previous courses.

MAKING JUDGMENTS:
The imparted knowledge will allow to acquire information useful to critically evaluate the functional and pathological changes of various organs and systems.

COMMUNICATION SKILLS:
Acquisition of oral communication skills through the use of proper scientific terminology.

LEARNING SKILLS:
The classes will be set to stimulate the student to deepen and integrate the topics discussed to develop an appropriate degree of autonomy.

Prerequisites

The student should have knowledge of the biochemistry and physiology of the cell and of the physiological mechanisms of the various apparatuses.

Contents

Frontal lessons (6 CFU; 48 h)
Introduction: pharmacokynetics and pharmacodynamics
Autonomic drugs:
Introduction to autonomic pharmacology
Muscarinic receptor agonist and antagonist
Cholinesterase-inhibiting drugs
Drugs acting on neuromuscular junction and autonomic ganglia
Catecholamine, sympathomimetic drugs and adrenergic receptor antagonists
Serotonin and Dopamine: physiological action and drugs

Drugs affecting cardiovascular function:
Inhibitors of renin and angiotensin system
Calcium blockers

Drugs with important actions on smooth muscle:
Histamine
The eicosanoids: prostaglandins, thromboxane, leukotrienes & related compounds

Drug therapy of inflammation:
NSAIDs
Corticosteroids

Drugs active in the central nervous system:
Sedative-Hypnotic drugs
Antiseizure Drugs
Antidepressant agents
Opioid agonist and antagonists
Drugs of abuse

Laboratory syllabus: (1 CFU; 12 hours)
Protein determination (Lowry)
Binding studies
ELISA

Teaching Methods

The course will be held with lectures involving the use of powerpoint presentations and exhibition of movies and laboratory practices.

Verification of learning

Verification of learning will take place through oral examination.The final rating takes into account several factors:
Quality of knowledge: correctness and consistency
Exposition: a) Capacity expressive b) Proper use of the specific language of the discipline; c) Logical and consequential capacities in the fitting of the contents; e) Ability to associate different topics by finding common points and establish a consistent overall design f) Ability to summarize through the use of symbolism on the matter, and the graphic expression of ideas and concepts, for example in the form of formulas, tables, equations.
Consequently, judgment may be:
A) Sufficient (from 18 to 20/30)
The candidate demonstrates little acquired knowledge, superficial level, many gaps. Expressive capacity modest, but still sufficient to support a coherent dialogue; Logical capacity and consequentiality in linking elementary level arguments; Poor synthesis capacity and graphical expression capabilities rather stunted; Poor interaction with the teacher.
B) Fair (21 to 23)
The candidate demonstrates discrete acquisition of notions, but little depth, few gaps; Expressive capacity more than enough to support a coherent dialogue; Acceptable mastery of scientific language; Logical capacity and consequentiality in the connection of moderate complexity topics.
C) Good (from 24 to 26)
The candidate demonstrates a wealth of notions of rather broad, moderate depth, with little gaps; Satisfactory expressive capacity and significant mastery of scientific language; Prominent dialogic and critical spirit; Good synthesis capability.
) Excellent (30)
The candidate demonstrates a wealth of extensive and in-depth knowledge, any irrelevant gaps; High expressive capacity and high level of mastery of scientific language; Excellent dialogic capacity, a strong ability to make connections between different topics.
Laude is given to candidates well above the average.

Texts

Goodman & Gilman,The pharmacological basis of therapeutics-Ed. 12a Mc Graw-Hill

- Rossi-Cuomo-Riccardi, Farmacologia, principi di base e applicazioni terapeutiche-Ed. Minerva Medica


- Golan, Tashjian, Armstrong, Galanter, Arnaout, Rese, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy Lipincott

More Information

The slides of the lectures will be available during the course

Questionnaire and social

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