6681 - GENERAL TOXICOLOGY
Academic Year 2021/2022
Free text for the University
ELIO MARIA GIOACCHINO ACQUAS (Tit.)
- Teaching style
- Lingua Insegnamento
|[50/24] TOXICOLOGICAL SCIENCES AND QUALITY ASSURANCE||[20/00 - Ord. 2017] PERCORSO COMUNE||6||48|
This course is meant to provide the student with the basic critical skills to proceed in the studies of toxicology (of drugs, addictive sustances, foods and environment). The student will learn the principles of toxicokinetic and toxicodynamic in order to be able to evaluate the toxic actions of substances and their mechanism(s) of toxicity.
Students must have passed the examination of Organic chemistry and have proficuously (above 65% of presences) attended the classes of General physiology and of Biochemistry & Molecular Biology. Attendance of the classes of General Toxicology is also mandatory (at least 65%) in order to be admitted at the final examination.
Principles of Toxicology. Routes, sites and frequency of exposure to toxicants. Interactions between toxicants.
Dose-response curves. Toxicity indexes.
Mechanisms of toxicity. Interactions toxicant-receptors, toxicant-excitable membranes and toxicant-mechanisms responsible of cellular homeostasis.
Toxicity on experimental animals. Acute lethality. Sub-acute, acute, sub-chronic and chronic toxicity. Reproductive and developmental toxicology. Mutagenesis tests.
Risk evaluation and predictive toxicology. Risk perception and evaluation. Epidemiology.
Mechanisms of adsorption, distribution, metabolism and clearance of toxicants.
Phase I and Phase II metabolic pathways and mechanisms of toxicants’ biotransformation.
Classes of this course will take place between 8 to 9 weeks and will have a weekly load of 6 hours. During these 8 to 9 weeks “in itinere” self-evaluation tests (perhaps also via web conections due tothe epidemiological situation) will also take place that may also be part of the examination. Due to the epidemiological situation and to its unpredictability classes may also take place through web streaming and the recordings of the lessons may be made available online.
Verification of learning
The final evaluation will be after an oral examination. However, during the course there will be for students the possibility to attend also at two or three self-evaluation tests whose scores may also be part of the final evaluation.
Klaassen Curtis D., Casarett & Doull’s – TOSSICOLOGIA – VII Ed. EMSI
Klaassen Curtis D., Watkins III John B. – Casarett & Doull ELEMENTI di TOSSICOLOGIA – Ed. Italiana a cura di Hrelia P. e Cantelli Forti G., Casa Editrice Ambrosiana
Slides used during classes will be made available to students as supporting material