FA/0183 - MOLECULAR MECHANISMS OF VITAL FUNCTIONS IN RESPONSE TO DRUGS
Academic Year 2021/2022
Free text for the University
MARIANGELA SERRA (Tit.)
- Teaching style
- Lingua Insegnamento
|[60/57] BIOLOGY||[57/20 - Ord. 2018] Bio-Molecolare||7||60|
The course on "Molecular mechanisms of vital functions and drug responses" aims to provide the student with theoretical and practical lessons for the acquisition of basic knowledge on vital functions and responses to drugs with the aim of understanding and predicting the mechanisms molecular, biochemical, functional and pharmacological that underlie specific vital functions
Knowledge bases of Biochemistry, Cytology and Anatomy
Molecular and structural bases of proteins - BIO10 (2+1CFU)
Protein structure: protein motifs and domains (2h)
Protein folding, unfolding and degradation (4h)
post translational modification of proteins (4h)
Protein sorting and transport and secretory pathway (6h)
Laboratory: study of native and denaturate protein structures (12)
Functional bases of individual eating behavior - BIO09 (2CFU)
Introduction to the sensory mechanisms involved (2h)
Physiology of taste and smell (6h)
Individual variability of gustatory and olfactory functions (4h)
Control factors of the relationship between gustatory perception and body composition (2h)
Function of taste receptors beyond taste (2h)
Molecular basis of drugs action BIO 14 (2CFU)
Introduction, pharmaceutical regulation, preclinical and clinical trials (2h)
Dynamics of absorption, distribution, metabolism and elimination of drugs. Equivalent drugs (2 h)
Molecular mechanisms of drug activity (6 h)
Pharmacogenetics (2 h)
Pharmacovigilance (2 h)
The teaching of the part “Molecular and Structural Bases of Proteins" (BIO10, 2+1CFU) will be taught by Dott.ssa Francesca Pintus (16 h) . The teaching will be delivered mainly in presence, integrated and "augmented" with online strategies, in order to guarantee its use in an innovative and inclusive way. At the end of the lectures, there is the laboratory part of the course (12 hours) that will be carried out in presence with the formation of small groups of students in order to ensure the correct performance of the activities.
The teaching of the part “Functional bases of individual eating behavior (BIO09, 2CFU) will be taught by Dr. Melania Melisi (16 hours). The teaching will be delivered mainly in presence, integrated and "augmented" with online strategies, in order to guarantee its use in an innovative and inclusive way.
Verification of learning
The learning of the skills acquired by the student will be verified through an oral interview. The grade will be awarded based on the assessment of the learning acquired by the student by the course teacher.
The final grade takes into account various factors:
Quality of knowledge, skills, skills possessed and / or manifested:
a) appropriateness, correctness and congruence of knowledge
b) appropriateness, correctness and congruence of skills
c) appropriateness, correctness and congruence of competences
a) Expressive capacity;
b) Appropriate use of the specific language of the discipline;
c) Logical capacity and consequentiality in the connection of contents;
e) Ability to link different topics by finding the common points and to establish a coherent general plan, that is to say by taking care of the structure, organization and logical connections of the exposition;
f) Ability to synthesis also through the use of the symbolism proper to matter and the graphic expression of notions and concepts, in the form, for example, of formulas, schemes, equations.
Availability to exchange and interaction with the teacher during the interview.
a) critical spirit;
b) self-assessment capacity.
Lehninger principles of biochemistry - D.L. Nelson, M.M. Cox.
Biochemistry - C.K. Mathews, K.E. van Holde.
Biochemistry - J.M. Berg, J.L. Tymoczko, L. Stryer.
Principles of Biochemistry - D. Voet, J.G. Voet, C.W. Pratt.
Physiology, Author: Stanfield
Physiology, Authors: Berne – Levy.
Human physiology, Authors: Rhoades & Panzer.
The pharmacological basis of therapeutics-Goodman &Gilman.
Molecular and Structural Bases of Proteins:
Lectures text files (including illustrations) are provided in Adobe Acrobat (.pdf) format.